Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CD131 mAb
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3 IL-5 and CSF Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP)
ABclonal Technology 647 Rabbit anti-Human GPRC5D
The protein encoded by this gene is a member of the G protein-coupled receptor family however the specific function of this gene has not yet been determined
ABclonal Technology 594 Rabbit anti-Human Nectin-4
Nectin-4 poliovirus Receptor-like 4 (PVRL4) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily that promotes intercellular adhesion by acting as a major component of adhesion junctions The extracellular domain of Nectin-4 consists of one Ig variable region (V) and two Ig constant regions (C) which mediate binding to measles virus and adjacent cells through trans-heterophile interactions with Nectin-1 Unlike other members of the connectin family which are widely expressed in adult tissues human Nectin-4 expression is largely limited to the blastoderm Studies have shown that Nectin-4 is overexpressed in cells from a variety of human solid tumors including pancreatic breast lung and ovarian cancers The expression pattern of Nectin-4 in normal tissues is limited so NECTIN-4 can be used as a novel therapeutic target for various human tumors
ABclonal Technology 647 Rabbit anti-Human CD131
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3 IL-5 and CSF Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP)
ABclonal Technology 647 Rabbit anti-Human CD131
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3 IL-5 and CSF Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP)
ABclonal Technology 647 Rabbit anti-Human CD89
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils monocytes macrophages and eosinophils where it mediates immunologic responses to pathogens It interacts with IgA-opsonized targets and triggers several immunologic defense processes including phagocytosis antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene
ABclonal Technology 647 Rabbit anti-Human CD47
This gene encodes a membrane protein which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin and it may play a role in membrane transport and signal transduction This gene has broad tissue distribution and is reduced in expression on Rh erythrocytes Alternatively spliced transcript variants have been found for this gene
ABclonal Technology 488 Rabbit anti-Human CD1c
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail Alternatively spliced transcript variants of this gene have been observed but their full-length nature is not known
ABclonal Technology 647 Rabbit anti-Human Syk
This gene encodes a member of the family of non-receptor type Tyr protein kinases This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses including proliferation differentiation and phagocytosis It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human CD30
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor is expressed by activated but not by resting T and B cells TRAF2 and TRAF5 can interact with this receptor and mediate the signal transduction that leads to the activation of NF-kappaB This receptor is a positive regulator of apoptosis and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported
ABclonal Technology 594 Rabbit anti-Human CD30
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor is expressed by activated but not by resting T and B cells TRAF2 and TRAF5 can interact with this receptor and mediate the signal transduction that leads to the activation of NF-kappaB This receptor is a positive regulator of apoptosis and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human CD116
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 a cytokine which controls the production differentiation and function of granulocytes and macrophages The encoded protein is a member of the cytokine family of receptors This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes Multiple transcript variants encoding different isoforms have been found for this gene with some of the isoforms being membrane-bound and others being soluble
ABclonal Technology 594 Rabbit anti-Human IL9
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells This cytokine stimulates cell proliferation and prevents apoptosis It functions through the interleukin 9 receptor (IL9R) which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes The gene encoding this cytokine has been identified as a candidate gene for asthma Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness
ABclonal Technology 700 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
